Professor of Medicine, UCLA
Cardiology
Dr. Alan M. Fogelman, MD
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Alan Fogelman works in the field of Cardiology. He went to medical school at David Geffen School of Medicine at UCLA. David Geffen School of Medicine at UCLA is a top medical university. David Geffen School of Medicine at UCLA has a rank of 13 in research and a 7 in primary care He received awards:"CMS Meaningful Use Stage 1 Certification", "Elected Member", "Super Doctor" and "Fellow (FACC)". Alan Fogelman is a published doctor. He published 90 publications, including: 'Tomatoes expressing the 6F Peptide Ameliorate the Increase in Oxidized Phospholipids in the Jejunum of Mice Fed Unsaturated Lysophosphatidylcholine or Western Diet.'
Publications
- Further evidence that high-density lipoprotein is a chameleon-like lipoprotein.
- Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis.
- Effect of Exposure to Atmospheric Ultrafine Particles on Production of Free Fatty Acids and Lipid Metabolites in the Mouse Small Intestine.
- Apolipoprotein A-I mimetics.
- ApoA-I Mimetic Peptide 4F Rescues Pulmonary Hypertension by Inducing MicroRNA-193-3p.
- Trying to harness the potential of HDL: wishful thinking or sound strategy?
- HDL lipid composition is profoundly altered in patients with type 2 diabetes and atherosclerotic vascular Disease.
- Searching for a Successful HDL-based Treatment Strategy.
- Transgenic 6F Tomatoes Act on the Small Intestine to Prevent Systemic Inflammation and Dyslipidemia Caused by Western Diet and Intestinally Derived Lysophosphatidic Acid.
- Heart Failure is Associated With Impaired Anti-Inflammatory and Antioxidant Properties of High-Density Lipoproteins.
- Ambient Ultrafine Particles Alter Lipid Metabolism and HDL Anti-Oxidant Capacity in LDLR-null Mice.
- Diesel Exhaust Induces Systemic Lipid Peroxidation and Development of Dysfunctional Pro-Oxidant and Proinflammatory High-Density Lipoprotein.
- A novel approach to oral apoA-I mimetic therapy.
- High-density lipoprotein and 4F peptide reduce systemic inflammation by modulating intestinal oxidized lipid metabolism: novel hypotheses and review of literature.
- Apolipoprotein a-I mimetic peptides inhibit expression and activity of hypoxia-inducible factor-1α in human ovarian cancer cell lines and a mouse ovarian cancer model.
- Effects of lipid-probe interactions in biochemical fluorometric methods that assess HDL redox activity.
- LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.
- HDL Mimetics Inhibit Tumor Development in Both Induced and Spontaneous Mouse Models of Colon Cancer.
- D-4F-mediated reduction in metabolites of Arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in LDLR null mice.
- A Biochemical Fluorometric Method for Assessing the Oxidative Properties of HDL.
- Anti-Inflammatory and Antioxidant Properties of HDLs Are Impaired in Type 2 Diabetes.
- Enhancement by LDL of transfer of L-4F and oxidized lipids to HDL in C57BL/6J mice and human plasma.
- Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with Coronary artery disease.
- Salutary effects of hemodialysis on low-density lipoprotein proinflammatory and high-density lipoprotein anti-inflammatory properties in patient with end-stage renal d...
- Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally.
- Dysfunctional High-Density Lipoprotein and the Potential of Apolipoprotein A-1 Mimetic Peptides to Normalize the Composition and Function of Lipoproteins.
- D-4F, an apoA-I mimetic peptide, inhibits proliferation and tumorigenicity of epithelial ovarian cancer cells by upregulating the anti-oxidant enzyme MnSOD.
- Treatment of patients with cardiovascular Disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function.
- Apolipoprotein A-I mimetic peptides prevent atherosclerosis development and reduce plaque inflammation in a murine model of diabetes.
- Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer.
- The complexity of high-density lipoproteins.
- Mitogen-activated protein kinase phosphatase-1 deficiency decreases atherosclerosis in apolipoprotein E null mice by reducing monocyte chemoattractant protein-1 levels.
- L-4F Differentially Alters Plasma Levels of Oxidized Fatty Acids Resulting in More Anti-inflammatory HDL in Mice.
- Structure and function of HDL mimetics.
- L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation.
- Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids.
- HDL as a biomarker, potential therapeutic target, and therapy.
- Abnormal function of high-density lipoprotein is associated with poor Disease control and an altered protein cargo in rheumatoid arthritis.
- A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.
- In vitro stimulation of HDL anti-inflammatory activity and inhibition of LDL pro-inflammatory activity in the plasma of patients with end-stage renal Disease by an apo...
- Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipo...
- The role of dysfunctional HDL in atherosclerosis.
- Apolipoprotein A-I mimetic peptides.
- Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I.
- Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy.
- Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients.
- Treatment with an apolipoprotein A-1 mimetic peptide in combination with pravastatin inhibits collagen-induced arthritis.
- The effect of apolipoprotein mimetic peptides in inflammatory disorders other than atherosclerosis.
- D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet.
- Lipoprotein inflammatory properties and serum amyloid A levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits.
- Structural requirements for antioxidative and anti-inflammatory properties of apolipoprotein A-I mimetic peptides.
- Differential association of hemoglobin with proinflammatory high density lipoproteins in atherogenic/hyperlipidemic mice. A novel biomarker of atherosclerosis.
- A novel anti-atherogenic role for COX-2--potential mechanism for the cardiovascular side effects of COX-2 inhibitors.
- Adenovirus-mediated expression of human paraoxonase 3 protects against the progression of atherosclerosis in apolipoprotein E-deficient mice.
- Peptide Mimetics of Apolipoproteins Improve HDL Function.
- Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice.
- Modifying the anti-inflammatory effects of high-density lipoprotein.
- Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2.
- D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet.
- High-density lipoprotein: is it always atheroprotective?
- Understanding changes in high density lipoproteins during the Acute phase response.
- Proinflammatory high-density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis.
- An apolipoprotein A-I mimetic works best in the presence of apolipoprotein A-I.
- High-density lipoprotein function recent advances.
- Oral small peptides render HDL antiinflammatory in mice and monkeys and reduce atherosclerosis in ApoE null mice.
- An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice.
- D-4F and statins synergize to render HDL antiinflammatory in mice and monkeys and cause lesion regression in old apolipoprotein E-null mice.
- When pouring water on the fire makes it burn brighter.
- The role of high-density lipoprotein in inflammation.
- Anti-inflammatory properties of HDL.
- D-4F, an apolipoprotein A-I mimetic peptide, inhibits the inflammatory response induced by influenza A infection of human type II pneumocytes.
- Antiinflammatory properties of HDL.
- Genetic basis of atherosclerosis: part II: clinical implications.
- PLTP deficiency improves the anti-inflammatory properties of HDL and reduces the ability of LDL to induce monocyte chemotactic activity.
- Genetic basis of atherosclerosis: part I: new genes and pathways.
- Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models.
- When good cholesterol goes bad.
- Oral D-4F causes formation of pre-beta high-density lipoprotein and improves high-density lipoprotein-mediated cholesterol efflux and reverse cholesterol transport fro...
- Aromatic residue position on the nonpolar face of class a amphipathic helical peptides determines biological activity.
- The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL.
- Apparent paradox of low-fat "healthy" diets increasing plasma levels of oxidized low-density lipoprotein and lipoprotein(a).
- Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels...
- Oral synthetic phospholipid (DMPC) raises high-density lipoprotein cholesterol levels, improves high-density lipoprotein function, and markedly reduces atherosclerosis...
- Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism.
- ATP-binding cassette transporter 1 participates in LDL oxidation by Artery wall cells.
- Influenza infection promotes macrophage traffic into arteries of mice that is prevented by D-4F, an apolipoprotein A-I mimetic peptide.
- Identification of genes induced by oxidized phospholipids in human Aortic endothelial cells.
- Oral administration of an Apo A-I mimetic Peptide synthesized from D-amino acids dramatically reduces atherosclerosis in mice independent of plasma cholesterol.
- Tomatoes expressing the 6F Peptide Ameliorate the Increase in Oxidized Phospholipids in the Jejunum of Mice Fed Unsaturated Lysophosphatidylcholine or Western Diet.
Schools
David Geffen School Of Medicine At UCLA University Of California Los Angeles
UCLA Hospital
University Of California Los Angeles
Procedures Preformed
- Cardiac Catheterization (incl. Coronary Angiography)
- Coronary Angioplasty, Atherectomy and Stent
Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomyopathy
- View All
Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
- Super Doctor
- Fellow (FACC)
Education
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UCLA Medical Center -
David Geffen School of Medicine at UCLA
Hospital
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Ronald Reagan UCLA Medical Center -
Santa Monica-UCLA Medical Center and Orthopaedic Hospital
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