Physician
Infectious Disease
Dr. Alan L. Rothman, MD
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Alan Rothman works in the field of Infectious Disease. He researched medicine at Boston University School of Medicine. Boston University School of Medicine has a rank of 30 in research and a 52 in primary care Alan L. Rothman is a published doctor. He has 101 papers published. The most current publication "Dengue vaccine: the need, the challenges and progress."
Publications
- Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells.
- Dengue vaccine: the need, the challenges and progress.
- Trials and Tribulations on the Path to Developing a Dengue Vaccine.
- Evaluation of Cardiac Involvement in Children with Dengue by Serial Echocardiographic Studies.
- A plasmid-based reporter system for live cell imaging of dengue virus infected cells.
- The spatial dynamics of dengue virus in kamphaeng phet, Thailand.
- DHIM Supporting Immunologic Investigations and the Identification of Immune Correlates of Protection.
- Characteristics of Mild Dengue Virus Infection in Thai Children.
- Post-translational intracellular trafficking determines the type of immune response elicited by DNA vaccines expressing Gag antigen of Human Immunodeficiency Virus Typ...
- Distinct Activation Phenotype of a Highly Conserved Novel HLA-B57-Restricted Epitope during Dengue Virus Infection.
- The two-faced T cell epitope: Examining the host-microbe interface with JanusMatrix.
- Reply to "Phenotypic Identification of Staphylococcus intermedius May Be Inaccurate".
- Dengue viral RNA levels in peripheral blood mononuclear cells are associated with disease severity and preexisting dengue immune status.
- Frequent In-Migration and Highly Focal Transmission of Dengue Viruses among Children in Kamphaeng Phet, Thailand.
- Analysis of Human Monoclonal Antibodies Generated by Dengue Virus-Specific Memory B Cells.
- Reply to Akbar et al.
- Metastatic Complications From Staphylococcus intermedius, a Zoonotic Pathogen.
- B-cell responses during primary and secondary dengue virus infections in humans.
- Preexisting Japanese encephalitis virus neutralizing antibodies and increased symptomatic dengue illness in a school-based cohort in Thailand.
- Dengue--How Best to Classify It.
- Intracellular cytokine production by dengue virus-specific T cells correlates with subclinical secondary infection.
- Development of antigen-specific memory CD8+ T cells following live-attenuated chimeric West Nile virus vaccination.
- Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand.
- Inferring the serotype associated with dengue virus infections on the basis of pre- and postinfection neutralizing antibody titers.
- Differential in vivo clearance and response to secondary heterologous infections by H2(b)-restricted dengue virus-specific CD8+ T cells.
- Classification of dengue illness based on readily available laboratory data.
- Sequential immunization with heterologous chimeric flaviviruses induces broad-spectrum cross-reactive CD8+ T cell responses.
- Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005.
- Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators.
- Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006.
- T lymphocyte responses to heterologous secondary dengue virus infections.
- Gene expression profiling of dengue infected human primary cells identifies secreted mediators in vivo.
- Cross-reactive memory CD4+ T cells alter the CD8+ T-cell response to heterologous secondary dengue virus infections in mice in a sequence-specific manner.
- TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais.
- Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
- Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans.
- Spatial and temporal clustering of dengue virus transmission in Thai villages.
- Viral replication and paracrine effects result in distinct, functional responses of dendritic cells following infection with dengue 2 virus.
- Human metapneumovirus reinfection among children in Thailand determined by ELISA using purified soluble fusion protein.
- Microevolution of Dengue viruses circulating among primary school children in Kamphaeng Phet, Thailand.
- Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner.
- Elevated levels of soluble ST2 protein in dengue virus infected patients.
- Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus.
- TRAIL is a novel antiviral protein against dengue virus.
- Antibody-dependent cellular cytotoxicity mediated by plasma obtained before secondary dengue virus infections: potential involvement in early control of viral replicat...
- Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonographic study.
- Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever.
- A comparative study of leptospirosis and dengue in Thai children.
- Evidence of vascular damage in dengue disease: demonstration of high levels of soluble cell adhesion molecules and circulating endothelial cells.
- Cellular immune activation in children with acute dengue virus infections is modulated by apoptosis.
- Relationship of thrombopoietin and interleukin-11 levels to thrombocytopenia associated with dengue disease.
- Punctual professor using passé procedures. Answer unclear.
- Cell type-specific mechanisms of interleukin-8 induction by dengue virus and differential response to drug treatment.
- Dengue virus-reactive CD8+ T cells display quantitative and qualitative differences in their response to variant epitopes of heterologous viral serotypes.
- Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion.
- Altered cytokine responses of dengue-specific CD4+ T cells to heterologous serotypes.
- Dengue Virus (DV) enhancing antibody activity in preillness plasma does not predict subsequent disease severity or viremia in secondary DV infection.
- Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: possible ro...
- Identification of murine poxvirus-specific CD8+ CTL epitopes with distinct functional profiles.
- Evolution of the intrahepatic T cell repertoire during chronic hepatitis C virus infection.
- Induction of human T cell-mediated immune responses after primary and secondary smallpox vaccination.
- Dengue: defining protective versus pathologic immunity.
- Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand.
- A blunted blood plasmacytoid dendritic cell response to an acute systemic viral infection is associated with increased disease severity.
- Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells.
- Dengue immune response: low affinity, high febrility.
- Quantitation of CD8+ T cell responses to newly identified HLA-A*0201-restricted T cell epitopes conserved among vaccinia and variola (smallpox) viruses.
- Immunology and immunopathogenesis of dengue disease.
- High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.
- Spatial and temporal circulation of dengue virus serotypes: a prospective study of primary school children in Kamphaeng Phet, Thailand.
- Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand.
- Dengue-specific T cell responses in peripheral blood mononuclear cells obtained prior to secondary dengue virus infections in Thai schoolchildren.
- Increased production of interleukin-8 in primary human monocytes and in human epithelial and endothelial cell lines after dengue virus challenge.
- Primary induction of human CD8+ cytotoxic T lymphocytes and interferon-gamma-producing T cells after smallpox vaccination.
- T cell responses to an HLA-B*07-restricted epitope on the dengue NS3 protein correlate with disease severity.
- Cytokine gene expression and protein production in peripheral blood mononuclear cells of children with acute dengue virus infections.
- Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections.
- Dose-related effects of smallpox vaccine.
- Human cytotoxic T lymphocyte responses to live attenuated 17D yellow fever vaccine: identification of HLA-B35-restricted CTL epitopes on nonstructural proteins NS1, NS...
- Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C.
- Identification and analysis for cross-reactivity among hantaviruses of H-2b-restricted cytotoxic T-lymphocyte epitopes in Sin Nombre virus nucleocapsid protein.
- Dengue: translating scientific progress into workable solutions.
- Genetic variations and relationship among dengue virus type 3 strains isolated from patients with mild or severe form of dengue disease in Indonesia and Thailand.
- Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study.
- Understanding the contribution of cellular immunity to dengue disease pathogenesis.
- Efficient dengue virus (DENV) infection of human muscle satellite cells upregulates type I interferon response genes and differentially modulates MHC I expression on b...
- The safety and tolerability of an HIV-1 DNA prime-protein boost vaccine (DP6-001) in healthy adult volunteers.
- Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.
- Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations.
- Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine.
- Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers.
- Hepatitis C virus-specific immune responses and quasi-species variability at baseline are associated with nonresponse to antiviral therapy during advanced hepatitis C.
- Increased activity of indoleamine 2,3-dioxygenase in serum from acutely infected dengue patients linked to gamma interferon antiviral function.
- Cross-Reactivity and Expansion of Dengue-Specific T cells During Acute Primary and Secondary Infections in Humans.
- Memory CD8+ T cells from naturally acquired primary dengue virus infection are highly cross-reactive.
- Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms.
- Extended interferon-alpha therapy accelerates telomere length loss in human peripheral blood T lymphocytes.
- Cellular immunology of sequential dengue virus infection and its role in disease pathogenesis.
- Early scientific progress.
- Dynamics of the CD8 T-cell response following yellow fever virus 17D immunization.
Schools
Boston University School Of Medicine
Med College Va
Boston Va Med Center
University Mass Med Center
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Education
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University of Massachusetts -
Virginia Commonwealth University Health System -
Boston University School of Medicine
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